Reproduction Abstracts

In the “KNDy hypothesis”, the latest concept explaining the control of GnRH secretion, the pulsatile GnRH signal is controlled by arcuate nucleus cells that produce kisspeptin (K), neurokinin B (N) and dynorphin (Dy). The interplay among these peptides involves one of them acting as a ‘pace-setter’, one as a ‘brake’, and the other as communicator of the final signal to the GnRH cells. To date the KNDy hypothesis has proven to be robust, but, if it...